Database : BCL-2 family (BCL2DB) Bacterial tyrosine kinases (BYKdb) Hepatitis B virus (HBVdb) Hepatitis C virus proteins (euHCVdb) Hepatitis C virus polyproteins (euHCVdb) Swiss-Prot UniProtKB clustered at 90+% sequence identity (UniProt90) UniProtKB clustered at 70+% sequence identity (UniProt70) UniProtKB clustered at 50+% sequence identity (UniProt50) UniProtKB Fungi (UniProtKB/Fungi) UniProtKB Metazoa (UniProtKB/Metazoa) UniProtKB Plants (UniProtKB/Plants) UniProtKB Prokaryotes (UniProtKB/Prokaryotes) UniProtKB Unclassified (UniProtKB/Unclassified) UniProtKB Viruses (UniProtKB/Viruses) AlphaFold 2 database / AlphaFoldDB (AF2DB) ESM Metagenomic Atlas high quality models clustered at 30+% sequence identity (ESMMAHQ30) Protein Data Bank ENT file coordinates (NPSA3DB) Protein Data Bank ENT file coordinates clustered at 95+% sequence identity (NPSA3D95) Protein Data Bank ENT file coordinates clustered at 25+% sequence identity (NPSA3D25) Protein Data Bank SEQRES (PDBSEQRES) Representative proteins with 3-D coordinates (PDBSEQRES95 + AF2DB50 + ESMMAHQ30)

Paste a HMMER 3 profile HMM below : help
You can build a profile HMM with HMMBUILD.

Number of results to display : 50010002000500010000

Profile HMM HMMSEARCH options :
Options controlling reporting thresholds:
- Report sequences <= this E-value threshold (-E) : 1e-061e-031e-021e-011.010.0100.0
   OR Report sequences >= this score threshold (-T) :
- Report domains <= this E-value threshold (--domE) : 1e-061e-031e-021e-011.010.0100.0
   OR Report domains >= this score threshold (--domT) :

Options controlling inclusion (significance) thresholds:
- Include sequences <= this E-value threshold (--incE) : 1e-061e-031e-021e-011.0
   OR Include sequences >= this score threshold (--incT) :
- Include domains <= this E-value threshold (--incdomE) : 1e-061e-031e-021e-011.0
   OR Include domains >= this score threshold (--incdomT) :

Options controlling acceleration heuristics:
- Turn all heuristic filters off (--max) : TrueFalse (less speed, more power)
- P-value threshold for the MSV filter (Stage 1) step (--F1) :0.0010.0020.0050.010.020.05 (roughly 2% of the highest scoring nonhomologous targets are expected to pass the filter)
- P-value threshold for the Viterbi filter (Stage 2) step (--F2) :0.00010.00020.00050.0010.0020.005
- P-value threshold for the Forward filter (Stage 3) step (--F3) :1e-62e-65e-61e-52e-55e-5
- Turn off composition bias filter (--nobias) : TrueFalse (increases sensitivity somewhat, but can come at a high cost in speed, especially if the query has biased residue composition)

Other expert options:
- Turn off composition bias filter (--nonull2) : TrueFalse
- Set # of comparisons done, for per-sequence E-value calculations (-Z) :
- Set # of significant seqs, for per-domain conditional E-value calculations (--domZ) :
- Set the random number seed (--seed) : (if 0: one-time arbitrary seed)