Network Protein Sequence Analysis (NPSA, NPS@) image
This site is a fork of the original PRABI NPS@ server


May 17th, 2024: NPS@ updated (see NEWS).


A brief introduction to MUSCLE
MUSCLE 5 is a novel algorithm which constructs an ensemble of high-accuracy MSAs with diverse biases by perturbing a hidden Markov model and permuting its guide tree. Confidence in an inference is assessed as the fraction of the ensemble which supports it. Ensemble analysis can improve confidence assessment in any inference from an MSA.

Availability in NPS@
MUSCLE is available :

The set to align cannot have more than 1,000,000 characters.
So, for example, you can use MUSCLE to align a set of similar sequences built from a BLAST search.

The -super5 option is used for computation.
The output format is CLUSTAL W.

NPS@ MUSCLE output example
The NPS@ MUSCLE output is divided into three parts.


Last modification time : Fri Dec 8 17:21:56 2023. Current time : Sun May 19 10:14:00 2024. User : public@

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